The Influence of 5-Lipoxygenase Inhibition in Allergic Rhinitis
نویسندگان
چکیده
منابع مشابه
In situ amplification of 5-lipoxygenase and 5-lipoxygenase-activating protein in allergic airway inflammation and inhibition by leukotriene blockade.
Leukotrienes are important mediators of the eosinophilic influx and mucus hypersecretion in the lungs in a murine model of asthma. We used in situ PCR in this model of human asthma to detect lung mRNA for 5-lipoxygenase (5-LO) and 5-LO-activating protein (FLAP), key proteins necessary for leukotriene synthesis. Lung tissue was obtained on day 28 from mice treated with i.p. (days 0 and 14) and i...
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ژورنال
عنوان ژورنال: International Archives of Allergy and Immunology
سال: 1995
ISSN: 1018-2438,1423-0097
DOI: 10.1159/000237065